BIOLOGICALLY ACTIVE PYRIMIDINE HYDARZONES

  • Sanchit Srivastav
  • Kanishk Luhach Department of pharmacy, IEC College of Engineering & Technology, Gr. Noida (UP), India-201308
  • Chhama Shukla Department of pharmacy, IEC College of Engineering & Technology, Gr. Noida (UP), India-201308
  • Rajender Yadav Department of pharmacy, IEC College of Engineering & Technology, Gr. Noida (UP), India-201308

Abstract

Pyrimidine constitutes an important class of heterocycles in drug discovery & is very well known for their anticancer, antimicrobial, antioxidant & antiviral activities. Hydrazones is a class of organic compounds with the structure R1R2C=NNH2. They are formed usually by the action of hydrazine on ketones or aldehydes & have efficient CNS depressant, analgesics activity. In the same context, Schiff bases of pyrimidine hydrazones can be prepared by the reaction of “4-(4-Chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid hydrazide†with various terpenes such as citral, camphor, furfuraldehyde & menthone to make Schiff bases individually by refluxing them in the presence of glacial acetic acid (as solvent) for at least 2hrs to yield their respective derivatives.

The present studies revealed that Pyrimidine hydrazone derivatives could be used to synthesize the compounds having potent biological activities such as anticancer, antimicrobial, antioxidant, CNS depressant, analgesic & antiviral activities. All the prepared derivatives were under investigation for their antimicrobial activity and likely to possess the same & desired action.

Keyword: Pyrimidine Hydrazones, Biological active Pyrimidine, Schiff Bases etc.

 

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Author Biographies

Kanishk Luhach, Department of pharmacy, IEC College of Engineering & Technology, Gr. Noida (UP), India-201308

Department of pharmacy, IEC College of Engineering & Technology, Gr. Noida (UP), India-201308

Chhama Shukla, Department of pharmacy, IEC College of Engineering & Technology, Gr. Noida (UP), India-201308

Department of pharmacy, IEC College of Engineering & Technology, Gr. Noida (UP), India-201308

Rajender Yadav, Department of pharmacy, IEC College of Engineering & Technology, Gr. Noida (UP), India-201308

Department of pharmacy, IEC College of Engineering & Technology, Gr. Noida (UP), India-201308

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1.
Srivastav S, Luhach K, Shukla C, Yadav R. BIOLOGICALLY ACTIVE PYRIMIDINE HYDARZONES. JDDT [Internet]. 15Nov.2015 [cited 30Mar.2020];5(6):14-7. Available from: http://jddtonline.info/index.php/jddt/article/view/1169