PLACEBO-CONTROLLED STUDY ON COMPARISON OF TWO HERBAL HYPOLIPIDEMIC AGENTS
Introduction: Hyperlipidemia, either primary or secondary causes atherogenetic abnormalities leading to coronary artery disease, cardiac arrest and arrhythmias. Herbal therapy for prevention or cure of Hyperlipidemia is replacing allopathic medicine due to their bioequivalence and good compliance features. This study was conducted to compare hypolipidemic effects of Garlic and Nigella sativa.
Place of Study: Study was conducted at Jinnah Hospital Lahore from July 2013 to December 2013. Seventy five hyperlipidemic patients were enrolled after getting written consent which was approved by Ethics committee of the hospital.
Grouping: They were divided in three equal groups comprising 25 patients in each group. Group-A was treated by Nigella Sativa, Group-B was advised to take Garlic 10 grams twice daily for two months. Group-C was on placebo.
Results: After two months therapy it was observed by statistical analysis that Nigella sativa decreased total cholesterol 12.4 mg/dl, triglycerides 16.7 mg/dl, and LDL cholesterol 27.3 mg/dl. HDL rise was 5.2 mg/dl. Garlic decreased total cholesterol 17.9 mg/dl, triglycerides 19.9 mg/dl and LDL cholesterol 14.8 mg/dl. HDL cholesterol rise was 8.0 mg/dl.
Conclusion: It was concluded from this study that there is little difference between hypolipidemic effects of two important and famous herbal medicines ie, Nigella sativa and Garlic.
2.A. Wertelecki, T. and Skorupinska, J. The influence of phytogenic extracts on performance, nutrient digestibility, carcass characteristics, and gut microbial status in broiler chickens. Journal of Animal and Feed Sciences 2003;12:583-596.
3. Iji, P.A., Saki, A. and Tivey, D.R. Body and intestinal growth of broiler chicks on a commercial starter diet. 1. Intestinal weight and mucosal development. British Poultry Science2001; 42:505-513.
4. Hernandez, F., Madrid, J., Garcia, V., Orengo, J. and MegÃas, M.D. Influence of two plant extracts on broilers performance, digestibility, and digestive organ size. Poultry Science 2004;83:169-174.
5. Demir, E., Sarica, S., Ozcan M.A. and Suicmez, M. The use of natural feed additives as alternatives for an antibiotic growth promoter in broiler diets. British Poultry Science2003; 44:S44-S45.
6. Lewis, M.R., Rose, S.P., Mackenzie, A.M. and Tucker, L.A. Effects of dietary inclusion of plant extracts on the growth performance of male broiler chickens. British Poultry Science2003; 44:S43-S44.
7. Bampidis, V.A., Christodoulou, V., Florou-Paneri, P., Christaki, E., Chatzopoulou, P.S., Tsiligianni, T. and Spais, A.B. Effect of dietary dried oregano leaves on growth performance, carcase characteristics and serum cho-lesterol of female early maturing turkeys. British Poultry Science 2005; 46:595-606. Park K. Parks text book of preventive and social medicine. 24th ed. Jabalpur India: Banarasi Das Bhanot, 2004: 272 â€“ 73.
8. Amooz Mehr, A. and Dastar, B. (2009) Effects of alcoholic extract of two herbs (garlic and thymus) on the per-formance and blood lipids of broiler chickens. Journal of Agri-cultural Sciences and Natural Resources 2009;16:61-72.
9. Sivam, G.P. Protection against helicobacter pylori and other bacterial infections by garlic. Journal of Nutrition 2001; 131:1106S-1108S.
10. Sarica, S., Ciftci, A., Demir, E., Kilinc, K. and Yildirim, Y. (2005) Use of an antibiotic growth promoter and two herbal natural feed additives with and without exogenous enzymes in wheat based broiler diets. South African Journal of Animal Science 2005; 35:61-72.
11. Freitas, R., Fonseca, J.B., Soares, R.T., Rostagno, H.S. and Soares, P.R. Utilization of garlic (Allium sati-vum L.) as hypolipidemic agent. Revista Brasileira de Zootecnia 2001;30:761-765.
12. Cross, D.E., Acamovic, T., Deans, S.G. and McDevitt, R.M. The effect of dietary inclusion of herbs and their volatile oils on the Hyperlipidemia. British Poultry Science 2002;43: 533-535.
13. Botsoglou, N.A., Christaki, E., Florou-Paneri, P., Giannenas, I., Papageor-giou, G., and Spais, A.B. The effectof a mixture of herbal essential oils or Î±-tocopheryl acetate on performance parameters and oxidation of body lipid. South African Journal of Animal Science 2004;34: 52-61.
14. Le PM,Benhaddou-Andaloussi A, Settaf A, Cherrah Y, Haddad PS. The petroleum ether extract of Nigella sativa exerts lipid lowering effect. J Ethanopharmacol. 2004:94(2-3): 251-9.
15.EI DakhaKhani M, Mady NL, Halim MA. Nigella sativa L. oil protects against induced hepatotoxicity and improves serum lipid profile. Arzneimittel for schunge 2010; 5(9):832-36
16.Raeesi, M., Hoe-ini-Aliabad, S.A., Roofchaee, A., Zare Shahneh, A. and Pirali, S. Effect of periodically use of garlic (Allium sativum) on hyperpatients. World Academy of Science, Engineering and Technology 2010;68:1213- 1219.
17.Islam, M.S. and Choi, H. Comparative effects of dietary ginger (Zingiber officinale) and garlic (Allium sativum) investigated in Hyperlipidemia. Journal of Medicinal Food 2008;11:152-159.
18. Kim, Y.J., Jin, S.K. and Yang, H.S. Effect of dietary garlic bulb and husk on hyperlipidemia. Poultry Science 2009;88:398-405.
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