FORMULATION, CHARACTERIZATION AND PHARMACOKINETIC EVALUATION OF NARINGENIN- LOADED GASTRORETENTIVE MUCOADHESIVE POLYMERIC NANOSYSTEM FOR ORAL DRUG DELIVERY

  • PANNEERSELVAM SUSEELA
  • KUMPATI PREMKUMAR ASSISTANT PROFESSOR, DEPARTMENT OF BIOMEDICAL SCIENCE, BHARATHIDASAN UNIVERSITY, TIRUCHIRAPPALLI, TAMIL NADU.
  • SUNDARA DHAKSHINAMURTHY SARASWATHY ASSISTANT PROFESSOR, DEPARTMENT OF BIOMEDICAL SCIENCE, BHARATHIDASAN UNIVERSITY, TIRUCHIRAPPALLI, TAMIL NADU.
DOI https://doi.org/10.22270/jddt.v5i2.1091

Abstract

ABSTRACT

Nanoparticles mediated oral drug delivery system has attracted great attention in pharmacology to attain improved therapeutic index of chemotherapeutic drugs. In the present study, naringenin (NRG) - loaded gastroretentive mucoadhesive polymeric nanoparticles has been designed and investigated its application in oral drug delivery system. Naringenin loaded polymeric nanoparticles (NMPN) were prepared by thermal decomposition mediated nanoprecipitation method. Formulated NMPN were characterized and investigated for its mucoadhesive properties by swelling and in vitro mucoadhesion studies. The results indicated that the formulated NPMN were in the size of 66±7nm by dynamic light scattering analysis and the maximum drug loading efficiency was observed around 94.6±0.28%. Further the drug release studies showed that NMPN exhibited sustained drug release in stimulated gastric fluid (SGF; pH=1.2). Pharmacokinetic studies revealed that the formulated NMPN are highly biocompatible and showed enhanced therapeutic efficacy compared to free naringenin. The overall findings demonstrated that the gastroretentive mucoadhesive polymeric nanoparticles can act as a promising candidate with gastroprotective applications in biomedical research.

Keywords: Naringenin, drug delivery, stimulated gastric fluid, mucoadhesive

Downloads

Download data is not yet available.
Statistics
166 Views | 199 Downloads
How to Cite
1.
SUSEELA P, PREMKUMAR K, SARASWATHY SD. FORMULATION, CHARACTERIZATION AND PHARMACOKINETIC EVALUATION OF NARINGENIN- LOADED GASTRORETENTIVE MUCOADHESIVE POLYMERIC NANOSYSTEM FOR ORAL DRUG DELIVERY. JDDT [Internet]. 14Mar.2015 [cited 22Feb.2020];5(2):107-14. Available from: http://jddtonline.info/index.php/jddt/article/view/1091
Issue
Vol 5 No 2 (2015): Volume 5, Issue 2, March-April, 2015
Section
Research

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).