APPROACHES TO OVERCOME NSAID INDUCED ULCERATION IN ARTHRITIC PAIN MANAGEMENT: PERSPECTIVES AND PROSPECTS

  • , Ganeshanand
  • Jeet Kamal Department of Quality Assurance, I.S.F. College of Pharmacy, Moga, Punjab, 142001
  • Ashish Baldi Department of Quality Assurance, I.S.F. College of Pharmacy, Moga, Punjab, 142001

Abstract

Rheumatoid arthritis is an auto-immune joint disorder involving pain and inflammation. Various approaches are used for pain management and relief from arthritis with single and multiple dose therapy. In single dose therapy, use of non-steroidal anti-inflammatory drugs like diclofenac aceclofenac, celicoxib etc. reported many side effects mainly leading to decrease in production of prostaglandin and holding the ulcer. High dosing frequency of these drugs is also a major factor of risk. Recently developed novel formulations are especially suitable for achieving controlled and delayed release profile with low risk of dose dumping. These systems have received great attention of pharmaceutical industry as they deliver accurate amount of drug at the right time and location thus increasing patient compliance and economic feasibility and avoiding drug associated side effects. Present review mainly deals with the problem of ulceration in pain management, various approaches to overcome this and specifically explore the possibilities to apply novel drug delivery systems for this purpose.

Keywords: Arthritis, Drug delivery systems, Gastroretentive, NSAIDs, Pain, Rheumatoid arthritis, Rheumatic pain management.

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Author Biographies

, Ganeshanand
Research Scholar, Department of Pharmacy, JJT University, Jhunjhunu, -333 001, Rajasthan, India
Jeet Kamal, Department of Quality Assurance, I.S.F. College of Pharmacy, Moga, Punjab, 142001

Department of Quality Assurance, I.S.F. College of Pharmacy, Moga, Punjab, 142001

Ashish Baldi, Department of Quality Assurance, I.S.F. College of Pharmacy, Moga, Punjab, 142001

Department of Quality Assurance, I.S.F. College of Pharmacy, Moga, Punjab, 142001

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How to Cite
1.
Ganeshanand , Kamal J, Baldi A. APPROACHES TO OVERCOME NSAID INDUCED ULCERATION IN ARTHRITIC PAIN MANAGEMENT: PERSPECTIVES AND PROSPECTS. JDDT [Internet]. 13Mar.2015 [cited 31Mar.2020];5(2):9-6. Available from: http://jddtonline.info/index.php/jddt/article/view/1069