HEPATOPROTECTIVE ACTIVITY OF CHENOPODIUM ALBUM LEAVES EXTRACT IN CCl4 INDUCED HEPATOTOXICITY IN RATS

  • Jyoti Parkash Department of Pharmaceutical Science, JJT University, Jhunjhunu-333001, Rajasthan, India
  • Kannubhai Rameshbhai Patel Shri B.M. Shah College of Pharmaceutical Education and Research, Modasa-383315, Gujarat, India

Abstract

Objective- Hepatoprotective activity of Chenopodium album leaves extract in CCl4 induced hepatotoxicity in rats.

Method- The present study has been undertaken to evaluate hepatoprotective activity of Chenopodium album leaves extract in CCl4 induced hepatotoxicity in rats. The study was carried out by comparing SGOT, SGPT, Alkaline Phosphate, Direct Bilirubin, Total Bilirubin and Total proteins level in serum of different groups of rats. Histopathological study was also done on liver tissue of the all group of animals and compared with standard, positive control and negative control groups.

Result- Rats treated with Chenopodium album leave extract caused a significant reduction in SGOT, SGPT, Alkaline phosphate, direct bilirubin, total bilirubin. Level of total proteins was found retrieving towards normalcy. Level of these enzymes was almost comparable to standard drug i.e. Silymarin. Hepatoprotective activity was confirmed by histopathological study of liver tissue of control and treated animals.

Conclusion- From results it can be concluded that Chenopodium album possess hepatoprotective activity against CCl4­ induced liver toxicity in rats.

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Author Biographies

Jyoti Parkash, Department of Pharmaceutical Science, JJT University, Jhunjhunu-333001, Rajasthan, India
Research Scholar, Department of Pharmaceutical Science, JJT University, Jhunjhunu-333001, Rajasthan, India
Kannubhai Rameshbhai Patel, Shri B.M. Shah College of Pharmaceutical Education and Research, Modasa-383315, Gujarat, India
Shri B.M. Shah College of Pharmaceutical Education and Research, Modasa-383315, Gujarat, India

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How to Cite
Parkash, J., & Patel, K. (2015). HEPATOPROTECTIVE ACTIVITY OF CHENOPODIUM ALBUM LEAVES EXTRACT IN CCl4 INDUCED HEPATOTOXICITY IN RATS. Journal of Drug Delivery and Therapeutics, 5(2), 88-93. https://doi.org/10.22270/jddt.v5i2.1063