HEPATOPROTECTIVE ACTIVITY OF MAHONIA LESCHENAULTII TAKEDA. (ROOT WOOD AND ROOT BARK) ON COUNTRY MADE-LIQUOR (CML) INDUCED HEPATOTOXICITY IN RATS

  • Pradeep Saha Department of Pharmacy, JJT University, Jhunjhunu, -333 001, Rajasthan, India
  • Kanu Bhai Ramesh Bhai Patel Shri. BM. Shah College of Pharmaceutical Education and Research, Modasa -383 315 Gujarat, India

Abstract

The hepatoprotective potential of Mahonia leschenaultii Takeda. (root wood and root bark) extract was evaluated in Country-Made Liquor (CML)-induced hepatotoxicity in Wister rats. The rats were made hepatotoxic by administering (CML) (3 ml/100g body weight/day in two divided doses) and corn oil (1 ml/100g body weight /day in a single dose) orally for 21 days. The administration of root wood and root bark of Mahonia leschenaultii Takeda. extract (200 mg/kg body weight) mixed with tween 80 (0.5% w/w) orally from day 15to day 21 along with CML. The different biochemical parameters tested are ALAT, ASAT, ALP, LDH, TGL, total protein, total cholesterol, Albumin, total bilirubin and direct bilirubin. The results were compared with standard drugs i.e. Silymarin (70 mg/kg body weight) orally. The histopathological study was carried out and histopathological changes were observed and compared. The study showed that the extract of root wood and root bark of Mahonia leschenaultii Takeda. is definitely a hepatoprotective agent and help in reduction of liver damage.

 

Key words: Hepatoprotective, Mahonia leschenaultii Takeda. Country-Made Liquor, Root wood, and Root bark.

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Author Biographies

Pradeep Saha, Department of Pharmacy, JJT University, Jhunjhunu, -333 001, Rajasthan, India
Research Scholar, Department of Pharmacy, JJT University, Jhunjhunu, -333 001, Rajasthan, India
Kanu Bhai Ramesh Bhai Patel, Shri. BM. Shah College of Pharmaceutical Education and Research, Modasa -383 315 Gujarat, India
Shri. BM. Shah College of Pharmaceutical Education and Research, Modasa-383 315 Gujarat, India

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Saha P, Patel KB. HEPATOPROTECTIVE ACTIVITY OF MAHONIA LESCHENAULTII TAKEDA. (ROOT WOOD AND ROOT BARK) ON COUNTRY MADE-LIQUOR (CML) INDUCED HEPATOTOXICITY IN RATS. JDDT [Internet]. 14Mar.2015 [cited 7Jul.2020];5(2):100-6. Available from: http://jddtonline.info/index.php/jddt/article/view/1062