MICROBIAL TRIGGERED COLON TARGETED COMPRESSION COATED TABLETS OF TENOXICAM: FORMULATION AND EVALUATION

  • Rupali Sarjerao Vagare Shree Santkrupa college of Pharmacy, Ghogaon, Karad.

Abstract

The present investigation deals with to formulation and evaluation of colon specific drug delivery system of Tanoxicam by compression coated tablet technique. Tenoxicam, Avicel pH101, HPMC K4M, Guar gum were used as components.Tenoxicam compression coated tablets were prepared and evaluated for differential scanning colorimetry (DSC), FTIR spectroscopy and in-vitro dissolution study without rat caecal content and with rat caecal content. The results suggest that Colon specific drug delivery system of Tenoxicam compression coated tablets were formulated successfully by using natural polymer such as Guar gum in combination with different concentration of HPMC.  Tablets were evaluated for drug content, hardness, thickness, friability, weight variation, in-vitro dissolution and all the results were found within the specification. As the concentration of HPMC in compression coat increased, drug release was decreased. Based on in-vitro drug release study, it was concluded that compression coated tablets with combination of 90% Guar gum and 10% HPMC could produce a successful drug targeting to the colon with minimal amount released in the stomach and small intestine for tenoxicam.

Keywords: Tenoxicam, Guar gum, HPMC K4M, compression coated tablet

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References

1. Verma S, Saini S, Rawat A, Kaul M. Formulation, Evaluation and Optimization of Osmotically Controlled Colon Targeted Drug Delivery System. J. Pharm. Sci. & Res. 2011; 3(9): 1472-85.
2. Manasa B, Krishnan SK, Ahmed MG, DR. Nagesh and Ramesh B. Formulation and in- vitro evaluation of colon targeted matrix tablets of Lornoxicam. Int. J. of pharm and chemical Sci. 2013; 2(1):259-65.
3. Kaur Sukhbir, Recent approaches for colon targeted drug delivery system, ijpcbs 2013, 3(2), 360-371.
4. Bhawna G, Lovekesh N, Singh S. Formulation and Gamma Scintigraphic Evaluation of Colon Targeted Drug Delivery Systems Of Tinidazole In Healthy Human Volunteers. JPBMS. 2011;7(16):1-9.
5. Chithaluru K, Tadikonda R. Formulation and Evaluation of Microbially triggered compression coated tablets of Ketorolac Tromethiamine. Der Pharmacia Lettre. 2011: 3 (4) :29-39
6. Bali V, Pathak K, Dev RK. Novel microbially triggered colon specific delivery system of 5-Fluorouracil: Statistical optimization, in vitro, in vivo, cytotoxic and stability assessment. Int. J. of Pharmaceutics.2011; 411: 142–51.
7. Godge G, Hiremath S. Colonic delivery of film coated meloxicam tablets using natural polysaaaharide- polymer mixture. Int. Current Pharmaceutical journal.2012; 1(9):264-71
8. Panwar MS, Goyal A. Visible Spectrophotometric Estimation of Tenoxicam from Tablets. International Journal of Pharmaceutical & Biological Archives 2012; 3(4):993-95.
9. Merck Index, 13thedn. Merck and com. Inc, White house station, 2001, 1632.
10. “British Pharmacopoeia”, Published by the deptt. Of health and stationary office under the license from the controller of her majesty; stationary office for the dept. of Health Minister, UK, 2002, 2477.
11. Mobiflex (tenoxicam)
12. Brittain HG. Analytical profile of Drug substances and excipients. 22:p.433-57.
13. Brittain HG. Analytical profile of Drug substances and excipients. 24:p.245-69.
14. Rowe RC, Sheskey PJ, Quinn ME. Handbook of pharmaceutical excipients. 6th ed.p.298-300.
15. Merck Index, 13thedn. Merck and com. Inc, White house station, 2001, 1632.
16. “British Pharmacopoeia”, Published by the dept. Of health and stationary office under the license from the controller of her majesty; stationary office for the dept. of Health Minister, UK, 2002, 2477.
17. Chatwal GR, Anand SK, Instrumental Methods of Chemical Analysis. 5th ed. Himalaya Publishing House.2002.p. 2.29
18. Chatwal GR, Anand SK. Instrumental Methods of Chemical Analysis. 5th ed. Himalaya Publishing House.2002.p. 2.719.
19. Pavia PL, Lampman GM, Kriz GS. Introduction to spectroscopy, 3rd ed.2001.p. 13-101
20. Remington. The Science and Practice of pharmacy. 21st edition. Lippincott Williams and wilkins. vol I. p. 889-902.
21. Indian Pharmacopoeia. Government of India, New Delhi: Controller of Publications; 1, 2007.p.183-84.
22. The United State Pharmacopoeia, 19 (USP NF). The Official Compendia of Standards, Asian Edition, 2000.p. 1945
23. Yadav AV, Yadav VB, Shete AS. Experimental Biopharmaceutics and Pharmacokinetics. 1st ed. Nirali Prakashan.2011.p.1.14-1.17
24. Bramhankar DM, Jaiswal SB. Biopharmaceutics and pharmacokinetics a treatise. Delhi: Vallabh Prakashan; 1995: 431-33
25. Nasr M, Hashem FM, Shaker DS, Saad IE , Ragaey R. Guar gum and hydroxy propyl methylcellulose compressed coated tablets for colonic drug delivery: in vitro and in vivo evaluation in healthy human volunteers. Drug Discoveries & Therapeutics. 2011; 5(2):90-95.
26. Turkoglu M, Ugurlu T. In vitro evaluation of pectin–HPMC compression coated 5-aminosalicylic acid tablets for colonic delivery.European Journal of Pharmaceutics and Biopharmaceutics. 2002; 53: 65–73.
27. Ugurlu T, Turkoglu M, Gurer US, Akarsu BG. Colonic delivery of compression coated nisin tablets using pectin/HPMC polymer mixture. European Journal of Pharmaceutics and Biopharmaceutics. 2007; 67: 202–210.
28. Macleod GS, Fell JT, Collett JH, Sharma HL, Smith AM. Selective drug delivery to the colon using pectin:chitosan:hydroxypropyl methylcellulose film coated tablets. International Journal of Pharmaceutics. 1999; 187: 251–257.
29. Ebube NK, Hikal AH, Wyandt CM, Beer DC, Miller LG, Jones AB. Sustained release of acetaminophen from heterogeneous matrix tablets: influence of polymer ratio, polymer loading and co-active on drug release. Pharm. Dev. Technol. 1997; 2: 161-70.
30. Ilango KB, Manisha M, Brinda P. Investigation of Colon Specificity of Novel Polysaccharide okra Mucilage-Film Coated With Enteric Materials. Int. J. of Pharma and Bio Sci. 2012; 3(2):53-62.
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Vagare R. MICROBIAL TRIGGERED COLON TARGETED COMPRESSION COATED TABLETS OF TENOXICAM: FORMULATION AND EVALUATION. JDDT [Internet]. 13Jan.2015 [cited 27Nov.2021];5(1):75-1. Available from: http://jddtonline.info/index.php/jddt/article/view/1051