IN-SILICO DOCKING INVESTIGATION, SYNTHESIS AND INVITRO ANTICANCER STUDY OF BENZOXAZOLE DERIVATIVES

  • G Shitha Devaki amma memmorial college of pharmacy
  • V.K KAMALA BHAI AMMA Department of Pharmaceutical Chemistry, Devaki Amma Memorial College of Pharmacy, Chelembra, Malappuram, Kerala, India-673634
  • G BABU Department of Pharmaceutical Chemistry, Devaki Amma Memorial College of Pharmacy, Chelembra, Malappuram, Kerala, India-673634
  • C.R. BIJU Department of Pharmaceutical Chemistry, Devaki Amma Memorial College of Pharmacy, Chelembra, Malappuram, Kerala, India-673634

Abstract

Benzoxazole derivatives display broad spectrum of biological and pharmacological activities. The main objective of the present study was to explore newer molecules with potent biological activity like anticancer activity. Insilico screening was done and compound with no violation in Lipinski rule of five and good docking score are selected for wet lab synthesize. Benzoxazole derivatives were synthesized and are evaluated for invitro anticancer studies.  Derivatives were synthesized using different benzaldehyde and anhydride derivative. The synthesized compounds were then established on the basis of IR, MASS and 1H NMR spectral data and screened for anticancer activity on Human breast cancer cell line (MCF-7). The derivative showed significant activity on cell line.

Keywords: Benzoxazole, dihydrophthalazine, anticancer, MTT assay.

 

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Author Biographies

V.K KAMALA BHAI AMMA, Department of Pharmaceutical Chemistry, Devaki Amma Memorial College of Pharmacy, Chelembra, Malappuram, Kerala, India-673634

Department of Pharmaceutical Chemistry, Devaki Amma Memorial College of Pharmacy, Chelembra, Malappuram, Kerala, India-673634

G BABU, Department of Pharmaceutical Chemistry, Devaki Amma Memorial College of Pharmacy, Chelembra, Malappuram, Kerala, India-673634

Department of Pharmaceutical Chemistry, Devaki Amma Memorial College of Pharmacy, Chelembra, Malappuram, Kerala, India-673634

C.R. BIJU, Department of Pharmaceutical Chemistry, Devaki Amma Memorial College of Pharmacy, Chelembra, Malappuram, Kerala, India-673634

Department of Pharmaceutical Chemistry, Devaki Amma Memorial College of Pharmacy, Chelembra, Malappuram, Kerala, India-673634

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How to Cite
Shitha, G., AMMA, V., BABU, G., & BIJU, C. (2014). IN-SILICO DOCKING INVESTIGATION, SYNTHESIS AND INVITRO ANTICANCER STUDY OF BENZOXAZOLE DERIVATIVES. Journal of Drug Delivery and Therapeutics, 4(6), 122-126. https://doi.org/10.22270/jddt.v4i6.1014